Vice President JD Vance emerged early Sunday morning from an extended round of high-stakes negotiations with Iranian officials in Islamabad, Pakistan, acknowledging that the two sides failed to reach an agreement to end the ongoing conflict—while signaling that the impasse could carry serious consequences for Tehran.

Speaking to reporters around 6:30 a.m. after what he described as a roughly 21-hour session, Vance said the talks were substantive but ultimately unsuccessful.

“The bad news is that we have not reached an agreement,” Vance said. “And I think that’s bad news for Iran, much more than it’s bad news for the United States of America.”

Flanked by special envoy Steve Witkoff and senior adviser Jared Kushner, Vance emphasized that the U.S. delegation had entered the talks prepared to negotiate in good faith and with flexibility—but that Iran refused to meet core American demands.

“We’ve made very clear what our redlines are, what things we’re willing to accommodate them on, and what things we’re not willing to accommodate them on — and we’ve made that as clear as we possibly could,” he said. “And they have chosen not to accept our terms.”

At the center of the deadlock was Iran’s nuclear program. Vance said the United States required an “affirmative commitment” that Iran would not pursue a nuclear weapon—something Iranian officials declined to provide.

“The president told us, you need to come here in good faith and make your best effort to get a deal,” Vance added. “We did that, and unfortunately, we weren’t able to make any headway.”

The talks—hosted by Pakistani Prime Minister Shehbaz Sharif and Field Marshal Syed Asim Munir—marked a rare direct engagement between senior U.S. and Iranian officials. Vance became the highest-ranking American official to meet face-to-face with leaders of Iran’s theocratic regime since the 1979 Islamic Revolution. He praised Pakistan’s leadership, noting that “whatever shortcomings” in the meeting were not due to the hosts.

The American delegation met with Iranian Foreign Minister Abbas Araghchi and Parliament Speaker Mohammad Bagher Ghalibaf. A major sticking point remained Iran’s control over the Strait of Hormuz—a critical global oil chokepoint through which a significant portion of the world’s energy supply flows.

The negotiations followed a fragile two-week ceasefire agreement reached days earlier, after President Donald Trump halted planned U.S. strikes on Iranian infrastructure roughly 90 minutes before a self-imposed deadline. Trump had expressed cautious optimism heading into the weekend.

“We’ll see what happens,” Trump said Saturday. “Look, regardless, we win. Regardless what happens, we win. We’ve totally defeated that country, and so let’s see what happens. Maybe they make a deal, maybe they don’t. It doesn’t matter. From the standpoint of America, we win.”

But by Sunday morning, the president’s tone had shifted dramatically.

In a series of lengthy posts on Truth Social, Trump confirmed the collapse of negotiations and announced a sweeping escalation: a U.S.-led naval blockade of the Strait of Hormuz.

“Iran is UNWILLING TO GIVE UP ITS NUCLEAR AMBITIONS,” Trump wrote, calling the negotiations productive in many respects but ultimately unacceptable due to Tehran’s stance on nuclear weapons.

“The meeting with Iran began early in the morning, and lasted throughout the night — Close to 20 hours,” he said. “I could go into great detail, and talk about much that has been gotten but, there is only one thing that matters — IRAN IS UNWILLING TO GIVE UP ITS NUCLEAR AMBITIONS!”

Trump also accused Iran of failing to uphold commitments to keep the Strait of Hormuz open, alleging the regime had created uncertainty by suggesting the presence of naval mines.

“They say they put mines in the water… but what ship owner would want to take the chance?” he wrote. “THIS IS WORLD EXTORTION, and Leaders of Countries… will never be extorted.”

Declaring immediate action, Trump announced: “Effective immediately, the United States Navy… will begin the process of BLOCKADING any and all Ships trying to enter, or leave, the Strait of Hormuz.”

He added that U.S. forces would interdict vessels that paid tolls to Iran and begin clearing any mines in the waterway, while warning of severe military retaliation for any Iranian aggression.

“Any Iranian who fires at us, or at peaceful vessels, will be BLOWN TO HELL!” Trump wrote.

The president framed the escalation as both a defensive measure and a continuation of broader U.S. military pressure in the region, claiming Iran’s capabilities had already been significantly degraded.

“Their Navy is gone, their Air Force is gone, their Anti Aircraft and Radar are useless,” he said, reiterating his longstanding position that “IRAN WILL NEVER HAVE A NUCLEAR WEAPON!”

Despite the collapse of talks, Trump insisted progress had been made on other fronts—but emphasized that none of it mattered without resolution on the nuclear issue.

“In many ways, the points that were agreed to are better than us continuing our Military Operations to conclusion,” he wrote. “But all of those points don’t matter compared to allowing Nuclear Power to be in the hands of such volatile, difficult, unpredictable people.”

The developments leave the region at a precarious crossroads, with diplomacy stalled, military pressure increasing, and one of the world’s most critical shipping lanes now at the center of a rapidly escalating standoff.